Is crossing two breeds more or less likely... produce health problems than breeding two purebreds?

First off, I need to clarify that it is not true that by crossing two breeds, you will always produce healthy progeny that are free from the genetic diseases of their purebred parents. Mixes and crosses can and do inherit genetic disorders, which is why it’s important to health test your dogs and be familiar with their genetic background whether you’re breeding mixes or purebreds. However, the idea that crossing two breeds will inevitably increase their risk for health problems moreso than breeding two purebreds would is false. In fact, crossing two breeds will always reduce the probability of the offspring having poor health due to genetic factors when compared to the probability of this occurring when breeding only the purebred parents with other purebreds. There is a well-documented scientific reason for this, a genetic principle called heterosis..

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2016 crossbreeding answers